The study evaluated the haematological, serum biochemical and reproductive effects of different levels of monosodium glutamate (MSG) orally administered to female rabbits. Forty Dutch-belted female rabbits aged between 24 and 26 weeks were randomly distributed into four experimental groups after the initial weights were recorded. Group A was the control while rabbit does in groups B, C and D received 1, 2, and 4 ml MSG/kg body weight (BW), respectively. Each group was replicated twice with 5 rabbit does per replicate in a completely randomized design in an experiment which lasted for a period of 12 weeks. The results showed that MSG treatments significantly (p<0.05) influenced the total weight gain, feed intake and feed conversion ratio. The haemoglobin, mean corpuscular haemoglobin concentration, mean corpuscular volume and the leukocytes were significantly (p0.05) influenced by MSG treatments when compared with the control group. However, administration of MSG at 4 ml MSG/kg BW significantly (p<0.05) increased the aspartate aminotransferase concentration of the treated rabbits. In conclusion, oral administration of MSG at 1 ml MSG/kg BW presented the best feed conversion ratio, total weight gain, reproductive and pre-weaning performance without any negative implications on the health status of the animals.