This study aimed to assess the ameliorative effects of vitamin C and Sida acuta leaf meal (SALM) on the performance, haematology, and serum biochemistry of cocks fed dietary aflatoxin B (AFB ) contaminated diets. A total of 150 Isa White 1 1 cocks of 24 weeks of age were distributed into five study groups: 1 (control), 2 (AFB diet), 3 (AFB diet + Vitamin C), 4 (AFB diet + 2.50 g/kg SALM) and 5 1 1 1 (AFB diet + 5.0 g/kg SALM). The inclusion of AFB significantly (P<0.05) 1 1 reduced the total weight gain despite significantly (P<0.05) increasing the feed intake, protein intake, energy intake and feed conversion ratio of birds in group 2. Also, a sharp (P<0.05) decrease in PCV and RBC as well as the differential white blood counts were noted among the birds in group 2. For serum biochemistry, a notable (P<0.05) decrease in serum proteins and abnormal elevations (P<0.05) in serum enzymes and creatinine with a reduction in the glucose were observed among birds in group 2. However, significant (P<0.05) restorations of these parameters were observed among the cocks fed vitamin C and varied inclusion levels of SALM. These findings underscore the potential of vitamin C and SALM as protective agents against AFB -induced toxicity in poultry diets.