This study was carried out to determine the effect of leaf meals of Crassocephalum crepidioides (CCLM) and Chenopodium ambrosiodes (CALM) on the performance and health status of Cobb 500 broiler chickens. One hundred and twenty day-old Cobb 500 broiler chicks were randomly distributed to four dietary treatments of 30 birds per treatment (10 birds/replicate) during a six-week feeding experiment. The treatments were designated as Diet 1 (Basal/control diet), Diet 2 (Basal + 0.20g Vitamin C/kg), Diet 3 (Basal +. 0.25g CCLM/kg) and Diet 4 (Basal + 0.25g CALM/kg). The dietary supplementation of CCLM and CALM feed additives significantly (p < 0.05) increased the body weight gain and improved the feed conversion ratio of the broiler chickens compared to the control treatment. The broiler chickens fed diets supplemented with CCLM and CALM had higher (p 0.05) were observed in the dressing percentage and relative organ weights of the broiler chickens across the treatments. The dietary supplementations of CCLM and CALM additives in the diets significantly (p < 0.05) lowered the serum alanine aminotransferase, cholesterol and creatinine contents of the broiler chickens compared to the control group. This study has shown that CCLM and CALM could be used as potential feed supplements in a broiler diet to enhance growth performance and improve the health status of broiler chickens during production.