Contamination of poultry feed with mycotoxins such as Aflatoxin flavus has been a major challenge to the poultry industry due to the resultant toxic effects it poses. Hence, any nutritional strategy to mitigate the effects of this contamination will be a novel approach to enhancing productivity of the birds. The aim of this experiment was to evaluate the influence of dietary zinc (Zn) and Vernonia amygdalina leaf meal (VALM) on haematobiochemical indices and growth indicators in cocks raised on diets containing aflatoxin B1 (AFB1). Atotal of 150 Isa White cocks of 24 weeks of age were allotted into 5 experimental diets: A (control), B (AFB1 diet), C (AFB1 diet + Zn), D (AFB1 diet + 2.50 g/kg VALM) and 5 (AFB1 diet + 5.0 g/kg VALM). Atotal of thirty birds were allotted to each treatment which was replicated five times with each replicate containing six birds in a completely randomized design. The growth performance parameters, haematological indices and serum biochemical indicators in cocks fed diet B were observed to be adversely affected significantly (P<0.05). However, significant (P<0.05) enhancements of the parameters were noticed among the cocks fed Zn and varied additions of VALM. The results highlight the capacity of Zn and VALM as veritable agents to mitigate the possible effects of AFB1 poisoning domestic chickens.